Resveratrol for Cancer and Heart Disease

by Wellness Warrior on April 3, 2009


What people use when they have cancer and want to get well with alternative treatment


Resveratrol is “Nature’s Medicine” for Cancer, Heart Disease and Much More

An article by Mike Adams from Natural News

Just how good is resveratrol at preventing cancer and heart disease? It’s so good that drug companies are trying to mimic its molecules in order to claim they’re “creating” a new drug to prevent heart disease.

But this is Mother Nature’s miracle drug — only it’s not a drug. It’s a molecule synthesized by plants for protecting themselves! And it turns out the same molecule can protect you from cancer, heart disease and a whole lot more.

I wanted you to read about the amazing benefits of resveratrol, so I put together this collection of quotes from top authors in the field. Read it to learn the truth about resveratrol that the drug companies and the FDA hope you never find out…

Authors’ Quotes on Resveratrol

cfor_cancerResveratrol is a naturally occurring phytoalexin produced by some higher plants in response to injury or fungal infection. Phytoalexinsare chemical substances produced by plants as a defense against infection by pathogenic microorganisms, such as fungi. Alexin is from Greek, meaning to ward off or to protect. Resveratrol may also have alexin-like activity for humans.
- PDR for Nutritional Supplements by Sheldon Saul Hendler and David Rorvik
- Available on Amazon.com


cfor_cancerGrape juice contains resveratrol, as does cranberry juice, but at levels that are ten times less than those in red. Resveratrol content in different food and beverages: (uG 100 G), OyG/125 ML)Grapes 1,500, Red wine 625, Peanuts 150, White wine 38, Peanut butter 50, Grape juice 65, Blueberries 3, Cranberry juice 65, Raisins 0.01; resveratrol concentration in red wine varies greatly from one grape variety to another and from one region to another, with values ranging from 1 to 13 mg/l.
- Foods that Fight Cancer by Richard Beliveau, Ph.D. and Denis Gingras, Ph.D.
- Available on Amazon.com


cfor_cancerWhen incubated with hepatoma cells, resveratrol induced Phase II detoxifying enzymes that detoxified and inhibited the proliferation of these cells. Resveratrol also inhibited the development of preneoplastic lesions when mice were exposed to tumor initiators and promoters. Grape skins, leaves, juice and red wine are all good sources of resveratrol.
- Herbal Medicine, Healing and Cancer: A Comprehensive Program for Prevention and Treatment by Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine
- Available on Amazon.com


cfor_cancerA series of laboratory experiments suggests that resveratrol inhibits the development of cancer in animals and prevents the progression of cancer. However, human research is still needed in this area. In another set of animal studies, resveratrol was shown to inhibit both the acute and chronic phases of inflammation.
- The Natural Pharmacy: Complete Home Reference to Natural Medicine by Schuyler W. Lininger, Jr. DC
- Available on Amazon.com


Italian researchers discovered something even more profound regarding the chemistry of resveratrol. They determined that this unique chemical revitalizes nerve cells. In fact, resveratrol induced portions of the nerves to regenerate, in other words, the nerves started growing again, a feat formerly deemed impossible. A reasonable conclusion is that resveratrol is a major protector of the genes, in other words, it prevents chromosome damage. Yet, grape extracts offer another mechanism of action.
- Dr. Cass Ingram’s Lifesaving Cures by Dr. Cass Ingram
- Available on Amazon.com


cfor_cancerResveratrol is an antioxidant found in many foods, but most abundandy in peanuts and red grapes. Red wine from cold climates (such as France) is a particularly good source of resveratrol. It is less concentrated in red wines from warmer climes such as California, Italy, Spain, or Portugal. Studies from the University of Illinois have shown that the number of early breast lesions and skin cancers in mice dropped dramatically when they were given high doses of resveratrol.
- AntioxidantsAgainst Cancer: How to activate your bod natural healing powers withtoday’s most protective and immune-boosting supplements and foods by Ralph Moss, PhD
- Available on Amazon.com


cfor_cancerHu zhang (Polygonum cuspidatum) is a Chinese herb actually a weed that is the world’s richest source of resveratrol,the phytochemical also found in red wine that has generated a huge buzz for its disease-preventive actions in the body. A large body o fresearch supports the role of resveratrol in resisting cancer, inflammation and heart disease. Resveratrol has been found to suppress the activation of inflammatory cytokines and COX-2, and shows special promise in preventing and slowing the progression of breast cancer. Resveratrol is also a potent antioxidant.
- AntioxidantsAgainst Cancer: How to activate your bod natural healing powers with today’s most protective and immune-boosting supplements and foods by Ralph Moss, PhD
- Available on Amazon.com


cfor_cancerVirtually every pathway for tumor growth and propagation is blocked by resveratrol. Researchers appear to have developed a consensus that low concentrations of resveratrol cannot only counteract tumor initiation but can inhibit tumor cell survival. Resveratrol targets the very machinery inside cells that promote tumor cell survival. It appears to be able to concentrate its action on tumor cells rather than healthy cells. Resveratrol has also has the ability to induce cancer cells, but not normal cells, to die off.
- You Don’t Have to be Afraid of Cancer Anymore by Bill Sardi
- Available on Amazon.com


cfor_cancerA partial estrogen receptor agonist itself, resveratrol is believed by some researchers to be an estrogen-receptor antagonistin the presence of estrogen, resulting in breast cancer inhibition. Finally, resveratrol has recently shown activity against herpes simplex vims types 1 and 2 in a dose-dependent manner. It appears to disrupt a critical early event in the viral reproduction cycle.
- PDR for Nutritional Supplements by Sheldon Saul Hendler and David Rorvik
- Available on Amazon.com


for_heartAn article in Life Sciences described a study of resveratrol and infarct size. A middle cerebral artery occlusion was induced in rats 15 minutes after pre-treatment with resveratrol. Resveratrol significantly reduced the total infarction volume (Huang et al. 2001b). Supplemental grape seed-skin extract is a good source of resveratrol.
- Disease Prevention and Treatment by The Life Extension Editorial Staff
- Available on Amazon.com


for_heartAnother of the key components of grapes is resveratrol. Resveratrol belongs to a group of compounds called phytoalexins that plants produce in self-defense against environmental stressors, such as adverse weather or attack by insects or microorganisms. Resveratrol has been identified in more than seventy species of plants, including mulberries and peanuts, but the flesh of grapes is an especially good source. Resveratrol acts as an antioxidant and has also been shown to reduce the buildup of plaque in arteries.
- The Encyclopedia of Healing Foods by Michael Murray, N.D. and Joseph Pizzorno, N.D.
- Available on Amazon.com


cfor_cancerResearch highlights a number of resveratrol effects relevant to the cardiovascular system: Antioxidant, Inhibits peroxidation of low-density lipoprotein (LDL), Reduces platelet aggregation. Resveratrol has also been shown to function as a cancer chemopreventive agent. Such agents reduce the incidence of tumorigenesis by intervening at one or more of the stages of carcinogenesis. In research, resveratrol demonstrated chemopreventive activity in assays representing three major stages of carcinogenesis: initiation, promotion, and progression.
- Medical Herbalism: The Science Principles and Practices Of Herbal Medicine by David Hoffman, FNIMH, AHG
- Available on Amazon.com



cfor_cancerAnderson Cancer Center reviewed dozens of studies on resveratrol and concluded that it exhibited anticancer properties against a widerange of tumor cells, including lymphoid and myeloid cancers, multiple myeloma, cancers of the breast, prostate, stomach, colon, pancreas, and thyroid, melanoma, head and neck squamous cell carcinoma, ovarian, carcinoma, and cervical carcinoma. The researchers concluded that”resveratrol appears to exhibit therapeutic effects against cancer.” Resveratrol may be one of the best antiaging substances around.
- The 150 Healthiest Foods on Earth: The Surprising, Unbiased Truth About What You Should Eat and Why by Jonny Bowden, Ph.D., C.N.S.
- Available on Amazon.com


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Harvard University Medical School, says the life span of all life forms tested so far east cells, fruit flies, worms, and mice have been dramatically lengthened by minute amounts of resveratrol. That’s one of the reasons resveratrol is touted (by me among others) as one of the best anti-aging supplements you can take. But you don’t have to take a supplement to get your daily dosage of this antiaging compound. Just make grapes a part of your diet! The skins of the dark (red, purple) grapes are the best source. The benefits of grapes don’t stop with resveratrol.
- The 150 Healthiest Foods on Earth: The Surprising, Unbiased Truth About What You Should Eat and Why by Jonny Bowden, Ph.D., C.N.S.
- Available on Amazon.com


cfor_cancerThis may also be why resveratrol has such powerful research showing it not only prevents cancer, but may actually be considered as a treatment. resveratrol stops cancer in a variety of ways, from blocking estrogens and androgens to modulating genes. It has even shown a 30-71 percent ability to block bone metastasis. resveratrol appears to moderate the body’s detrimental inflammatory response to injury of the brain and spinal cord. It has also been shown to protect on many levels, including the antioxidant level, against heart and blood vessel disease.
- Spiritual Nutrition: Six Foundations for Spiritual Life and the Awakening of Kundalini by Gabriel Cousens, M.D.
- Available on Amazon.com


cfor_cancerPezzuto and colleagues were able to show that resveratrol was effective during all three phases of the cancer process: initiation, promotion, and progression. For example, resveratrol displayed antimutagenic and antioxidant activity, providing greater protection against DNA damage than vitamins C, E, or beta-carotene. UIC researchers showed that resveratrol restored glutathione levels, considered by some the most essential of antioxidants (Jang et al. 1999).
- Disease Prevention and Treatment by The Life Extension Editorial Staff
- Available on Amazon.com


for_heartOther studies, in animals and in vitro, have shown that resveratrol can inhibit the oxidation of LDL-cholesterol and, more recently, that it can reduce smooth muscle cell proliferation, believed to be one of the requisites of atherogenesis, by 70-90%, in a dose-dependent pattern. Red wine extract and resveratrol have shown equally significant cardioprotective effects in animal models of myocardial ischemic reperfusion injury. Additional evidence suggests that resveratrol also has estrogenic effects that may also provide cardiovascular protection.
- PDR for Nutritional Supplements by Sheldon Saul Hendler and David Rorvik
- Available on Amazon.com


cfor_cancerGrapes, as well as many berries and some nuts, contain a phytoalexin component called resveratrol that has shown cancer chemopreventive activity. Resveratrol has been found to act as an antioxidant, antimutagen, and anti-inflammatory. It has also been shown to inhibit the development of breast cancer and induce antiprogression activity in human myelocytic leukemia. The highest levels of resveratrol (up to one hundred times more than grapes) are found in grape leaves.
- Herbal Medicine, Healing and Cancer: A Comprehensive Program for Prevention and Treatment by Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine
- Available on Amazon.com


cfor_cancerIn 1997, a team led by pharmacy professor John Pezzuto announced that a substance in red wine, which was later named resveratrol, inhibited the onset and progression of cancer in mice. UIC reported that resveratrol is one of a group of compounds called phytoalexins that are produced in plants during times of environmental stress, such as adverse weather or insect, animal, or pathogenic attack. Resveratrol has been identified in more than 70 species of plants, including mulberries and peanuts, but the skins of red grapes are a particularly rich source (Jang et al. 1999).
- Disease Prevention and Treatment by The Life Extension Editorial Staff
- Available on Amazon.com


cfor_cancer

Resveratrol is a phytochemical found in grapes that has proven to be effective against cancer in cell and animal studies. It inhibits cancer initiation, promotion, and progression: the three major stages of cancer development. Saponins are phytochemicals found in legumes, most notably soybeans. They have the ability to combine oil and water, which helps them bind to cholesterol and increase its excretion from the body. They also appear to have anticancer properties, as they interfere with the process by which DNA reproduces.
- Foods That Fight Disease: A Simple Guide to Using and Understanding Phytonutrients to Protect and Enhance Your Health by Laurie Deutsch Mozian, M.S., R.D.

- Available on Amazon.co

cfor_cancer

There are a few leaders in the antioxidant army selenium, vitamin E, and resveratrol. In a recent study from Sweden, low selenium levels appeared to increase a persons risk for getting a certain kind of RA. Some experts think raising your selenium intake might even help to reduce your swelling and pain. Low vitamin E levels, on the other hand, raised the risk for all types of RA.Boost your selenium levels with seafood, mushrooms, dairy, and whole wheat. Rich sources of vitamin E include fortified cereals, vegetable oils, peanuts, and fish. Resveratrol mainly comes from grapes.
- Eat and Heal (Foods That Can Prevent or Cure Many Common Ailments) by the Editors of FC&A Medical Publishing
- Available on Amazon.com


cfor_cancer

Since resveratrol was only recently identified, no definitive human studies have been done. However, the cancer-preventive effects it shows in the lab and in animals is sure to lead to more research. Resveratrol was recently discovered by John Pezzuto and his team from the University of Illinois. A study published in the January 10, 1997, issue of Science detailed their attempts to track down anticancer substances in readily available foods. After hundreds of tests, the grape came out with the highest marks, inhibiting three different stages of cancer development.
- The Natural Pharmacist: Your Complete Guide to Reducing Cancer Risk by Richard Harkness
- Available on Amazon.com


for_heartThe compound of most interest is resveratrol, a hydroxystilbene first isolated from the roots of the white hellebore (Veratrum album var. grandiflorum). Hydroxystilbenes are found in a variety of plants, many unrelated. They are a prominent component of many species of the Polygonaceae family (Rheum, Polygonum spp.) but the richest source is found in grape skins and red wine. Resveratol is an antioxidant, anti-inflammatory, antiplatelet and antiallergy agent with demonstrated cancer-preventative activity (Cheong et al).
- The Constituents of Medicinal Plants: An Introduction to the Chemistry and Therapeutics of Herbal Medicine by Andrew Pengelly
- Available on Amazon.com


cfor_cancer

Nearly 100 scientific studies have attributed other cancer-fighting effects to resveratrol. Scientists at the Chungang University in Seoul, Korea, found that it deactivates some forms of the liver enzyme. This enzyme is necessary to transform many chemicals into a carcinogenic form. Their research was confirmed by the U.S. National Cancer Institute and the Samuel Lunenfield Research Institute in Toronto, which further learned that resveratrol stops the liver from processing chemicals such as deadly dioxin into a carcinogenic form.
- Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies by Phyllis A. Balch, CNC
- Available on Amazon.com


for_heartGrape skins contain resveratrol, a type of plant estrogen, also called a phytoestrogen. In your body resveratrol fights inflammation and prevents blood clots. Grape skins also contain the powerful flavonoid quercetin. It works as an antioxidant to prevent the low-density lipoprotein (LDL or “bad”) cholesterol from building up in your artery walls and blocking blood flow to your heart and brain. It also stops your blood from turning sticky and clumping together. Blood moves through your arteries more easily, taking some of the pressure off your heart and reducing your risk of stroke.
- Eat and Heal (Foods That Can Prevent or Cure Many Common Ailments) by the Editors of FC&A Medical Publishing
- Available on Amazon.com


for_heartResveratrol is a compound found in red wine that has potent antioxidant activity. Preliminary research has demonstrated cardiovascular benefit and possible anticancer properties.
- Prescription for Natural Cures: A Self-Care Guide for Treating Health Problems with Natural Remedies Including Diet and Nutrition, Nutritional Supplements, Bodywork, and More by James F. Balch, M.D. and Mark Stengler, N.D.
- Available on Amazon.com


cfor_cancer

Trials to determine the effects of resveratrol on the three stages of cancer were completed without toxicity to blood-forming cells. The following studies illustrate the many pathways resveratrol employs to inhibit cancer: Italian researchers recently determined that resveratrol exhibited a protective role against colon carcinogenesis, with the defense attributed to changes occuring in Bax protein, which encourages apoptosis, and expression (Tessitore et al. 2000).
- Disease Prevention and Treatment by The Life Extension Editorial Staff
- Available on Amazon.com


cfor_cancer

Scientists have proven that resveratrol works by reducing NF kappaB, thereby stopping the breast-cancer activity. There is plenty of science to show that resveratrol is a potent anti-breast cancer and highly protective nutrient. The bioflavonoid quercetin, found in fresh vine ripened fruit and available as a nutritional supplement, induces death in breast cancer cells. Quercetin demonstrated the ability to prevent environmental chemicals from promoting estrogen driven breast cancer.
- Mastering Leptin: The Leptin Diet, Solving Obesity and Preventing Disease, Second Edition by Byron J. Richards, CCN
- Available on Amazon.com


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Suppressing the growth cycle allows for a critical phase in cellular development refened to as differentiation, that is, an atypical cell becomes more typical. Resveratrol appears a promising anticancer agent for both hormone-dependent and hormone-independent breast cancers. At high concentrations, resveratrol caused suppression of cell growth in three breast cancer cell lines: ER-positive KPL-1 and MCF-7 and ER-negative MKL-F. Growth inhibition was credited in part to upregulation of Bax protein and activation of caspase-3 (a key mediator of apoptosis in mammalian cells).
- Disease Prevention and Treatment by The Life Extension Editorial Staff
- Available on Amazon.com


boy_11A disturbing but predictable trend is emerging in the resveratrol supplier arena. Every week a new, fly-by-night, company starts up selling resveratrol. They use Google sponsored ads to promote their products and make outrageous claims, while hiding the actual trans-resveratrol content of their products. None of these companies passed the Consumer Lab evaluation of resveratrol brands and none existed just one or two years ago. Many, such as Vivex by Shaklee, are MLM schemes whose products contain very little actual resveratrol. Consumer Lab, an independent testing authority, evaluated the major brands recently. The highest potency products that passed their evaluation were Biotivia, Transmax and Bioforte.

A product by Life Extension Co. failed badly with only 26% of the claimed resveratrol. Vivex did not participate in the test, and no company with a name made up from the word resveratrol passed the tests. This is clearly a case of buyer beware. Look for a reputable company with the resources and experience necessary to produce a quality resveratrol supplement.

Spellings: Resveratral, Reversatrol, Reversatral, Resvaratrol, Resvaratral


warning

Dosage is important

finally, when mega-dose resveratrol was put to the test in the first study involving warm-blooded animals, the animals fed mega-dose resveratrol did not live as long as animals placed on a normal-calorie diet. Many resveratrol pills sold online and in retail stores suggest mega-doses of resveratrol (360 mg and 1565 mg) on their label, doses that shortened the lives of lab animals. Lower doses, like those found in 3-5 glasses of red wine, or in Longevinex(R) (100 mg resveratrol), appear to be more efficacious.

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