A cocktail of vitamins, minerals and herbals may delay the major aspects of the ageing process and extend lifespan by 10 per cent, according to a mouse study from Canada.
Mice fed a supplement containing 30 dietary ingredients did not experience a 50 per cent loss in daily movement like other non-supplemented animals, according to findings published in the current issue of Experimental Biology and Medicine.
“For ageing humans maintaining zestful living into later years may provide greater social and economic benefits than simply extending years of likely decrepitude,” said Rollo.
“This study obtained a truly remarkable extension of physical function in old mice, far greater than the respectable extension of longevity that we previous documented. This holds great promise for extending the quality of life of ‘health span’ of humans,” he added.
“Dosages were derived from recommended human doses adjusted for body size and the 10-fold higher metabolic rate of mice,” explained the researchers.
Results showed maintenance of youthful levels of locomotor activity into old age in the supplemented animals, whereas old non-supplemented mice showed a 50 per cent loss in daily movement, said the researchers. This was accompanied by a loss of mitochondria activity, and declines in brain signalling chemicals relevant to locomotion, such as striatal neuropeptide Y. This chemical is associated with a range of functions, including maintaining energy balance, as well as effects in memory and learning.
“Although identifying the role of specific ingredients and interactions remains outstanding, results provide proof of principle that complex dietary cocktails can powerfully ameliorate biomarkers of aging and modulate mechanisms considered ultimate goals for aging interventions,” stated Rollo and his co-workers.
The supplement was composed of vitamins B1, B3 (niacin), B6, B12, C, D, E, folic acid, beta-carotene, CoQ10, rutin, bioflavonoids, ginko biloba, ginseng, green tea extract, ginger root extract, garlic, L-Glutathione, magnesium, selenium, potassium, manganese, chromium picolinate, acetyl L-carnitine, melatonin, alpha-lipoic acid, N-acetyl cysteine, acetylsalicylic acid, cod liver oil, and flax seed oil.
The study was funded by the Natural Sciences and Engineering Research Council of Canada.
Experimental Biology and Medicine
2010, Vol. 235, Pages 66-76, doi:10.1258/ebm.2009.009219
“Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging”
Authors: V. Aksenov, J. Long, S. Lokuge, J.A. Foster, J. Liu, C.D. Rollo
The full journal paper is available free to access here .
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